Department of Rehabilitation Sciences

Alexander Mdzinarishvili, PhD

Assistant Professor


Contact Information:

(405) 271-2131 Ext. 47128

Alexander-Mdzinarishvili@ouhsc.edu


Education:

Ph. D. in Physiology and Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, 1990
M.S. in Physiology/Neuroscience, Institute of Physiology, Georgian Academy of Science, Tbilisi, Republic of Georgia, 1985
B.S. in Biology, Georgia State University, Tbilisi, Republic of Georgia, 1980     


Teaching:

Professional Program:
AHS 8275 Neuroscience (course coordinator)
PHTH 8172 Measurement in Clinical Practice (course coordinator)


Research Interests:

Translational research of brain stroke and edema formation
Translational research of neural stem cells under brain stroke conditions 


Lab Website(s):

Brain Stroke and Rehabilitation Research Lab


Selected Publications:

  • Sadana P., Coughlin L., Burke J., Woods R., Mdzinarishvili A. (2015) Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: possible association with AQP4 modulation. J. of the Neurological Sciences DOI: 10.1016/j.jns.2015.04.042
  • Geldenhuys W. J., Mdzinarishvili A., Carroll R., Lin L., (Dec., 2014) The mito-NEET ligand NL-1 protection in transient ischemic stroke through an ERK1/2 kinase pathway. Journal of  Neurochemistry (submitted)
  • Mdzinarishvili A., Sutariya V., Talasila P., Aring D., Geldenhuys W., Sadana P., (2013)  Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke. J. Drug   Delivery and Translational Research (2013) 3:pp.309–317. (DDTR - Best paper 2013 award recipient)
  • Mdzinarishvili A., Sumbria R., Lang D., Klein J., (2012) Ginkgo Extract EGb761 Confers Neuroprotection by Reduction of Glutamate Release in Ischemic Brain. J. Pharmacy and  Pharm. Sci., 15(1), pp. 94 - 102.
  • Lang D., Kiewert C., Mdzinarishvili A., Schwarzkopf T., Sumbria R., Hartmann J.,  Klein J.,  (2011) Neuroprotective Effects of Bilobalide are Accompanied by a Reduction of Ischemia- Induced Glutamate Release in vivo. J. Brain Research 1425, pp. 155-63.
  • Kiewert C., Mdzinarishvili A., Hartmann J., Bickel U.,  Klein J., (2010) Metabolic and  Transmitter Changes in Core and Penumbra after Middle Cerebral Artery Occlusion in Mice. J. Brain Research  1312, pp. 101-107.
  • Paulson, J.R., Yang, T., Selvaraj P.K., Mdzinarishvili A., Van der Schyf, C.J., Klein, J., Bickel, U., Abbruscato T.J., (2010) Nicotine Exacerbates Brain Edema During in vitro and in vivo Focal Ischemic Conditions. J. Pharmacol. Exp. Ther.,332(2), pp. 371-379.
  • Hao J., Mdzinarishvili A., Abbruscato T.J., Klein J., Geldenhuys W.J., Van der Schyf C.J.,  Bickel U., (2008) Neuroprotection in Mice by NGP1-01 after Transient Focal Brain Ischemia. J. Brain Research, 1196, pp. 113-120.
  • Mdzinarishvili A., Kiewert C., Kumar V., Hillert M., Klein J., (2007) Bilobalide Prevents Ischemia-induced Edema Formation in vitro and in vivo. Neuroscience, 144(1), pp. 214-222.  
  • Crews F., Mdzinarishvili A., Kim D., He J. and Nixon K., (2006) Neurogenesis in Adolescent Brain is Potently Inhibited by Ethanol. Neuroscience, 137(2), pp. 437-445.