Michael B. Stout, PhD

Stout

Senior Research Scientist

E-mail: Michael Stout

(405) 271-8001 Ext. 41177


 

Postdoctoral Fellow, Basic Biology of Aging, Kogod Center on Aging, Mayo Clinic, 2011-2016

PhD, Nutrition & Metabolism, Ohio State University, 2005-2011

MA, Exercise Physiology, University of Central Florida, 2003-2005

BS, Engineering Technology, Bowling Green State University, 1996-2001

Selected publications, see CV for complete list:

Stout MB, Justice JN, Nicklas BJ, Kirkland JL. Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty. Physiology. In Press

Li R, Steyn FJ, Stout MB, Lee K, Cully TR, Calderon JC, Ngo ST. Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles. J. Physiology. In Press

Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating health span in pre-clinical models of aging and disease: Guidelines, challenges and opportunities for geroscience. J. Gerontol. A. Biol. Sci. Med. Sci. In Press

Kirkland JL, Stout MB, Sierra F. Resilience in aging mice. J. Gerontol. A. Biol. Sci. Med. Sci. In Press

Chen VP, Gao Y, Geng L, Stout MB, Jensen MJ, Brimijoin S. Butyrylcholinesterase deficiency promotes adipose tissue growth and hepatic lipid accumulation in male mice on high-fat diet. Endocrinology. 157(8):3086-3095, 2016.

Schafer MJ, White TA, Evans GL, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes. 65(6):1606-1615, 2016.

Stout MB, Steyn FJ, Jurczak MJ, Camporez JPG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, Santos RDS, Frank AP, White TA, Monroe DG, Singh RJ, Verzosa GC, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL. Late-life administration of 17α-estradiol alleviates metabolic and inflammatory dysfunction without inducing feminization. J. Gerontol. A. Biol. Sci. Med. Sci. In Press

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. JAK inhibition alleviates the cellular senescent-associated secretory phenotype and frailty in old age. Proc. Natl. Acad. Sci. USA. 112(46):E6301-E6310, 2015.

Stout MB, Swindell RW, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM. Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice. Oncotarget. 6(29):26702-26715, 2015.

Zhu Y, Tchkonia T, Stout MB, Giorgadze N, Wang L, Li P, Holtz-Heppelmann CJ, Bouloumié A, Jensen MD, Bergen III HR, Kirkland JL. Inflammation and the depot-specific secretome of human fat cell progenitors.  Obesity. 23(5):989-999, 2015.

Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging Cell. 14(4):644-658, 2015.

Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J. Hepatol. 62(5):1156-1163, 2015.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging. 6(7):575-586, 2014.

Stout MB, Tchkonia T, Kirkland JL. The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence. Adipose tissue and Adipokines in Health and Disease – Second Edition, 2014.

Recent funding, see CV for complete list

Mechanisms of metabolic, inflammatory, and healthspan enhancement by 17α-estradiol
Agency
:  NIH/NIA
Type:  K99/R00
Amount:  $761,699 (direct)
Period:  September 2016-August 2021

LC/MS Multiplex Protein Quantification for assessing Age-related Proteostasis Dynamics
Agency
:  Oklahoma Nathan Shock Center
Type:  Competitive Pilot Research Program
Amount:  $11,550 (direct)
Period:  June 2016-May 2017

Mitigation of obesity and associated morbidities by 17α-estradiol: A novel therapeutic?
Agency
:  Minnesota Obesity Center
Type:  Competitive Pilot Research Program
Amount:  $25,000 (direct)
Period:  April 2015-March 2016

Somatotrophic drive and white adipose tissue cellular senescence
Agency
:  Mayo Clinic Robert and Arlene Kogod Center on Aging Research Endowment Fund
Type:  Competitive Career Development Award, Multi-campus
Amount:  $115,384 (direct)
Period:  July 2013-June 2015

The central focus of Dr. Stout’s research program is to understand how metabolic disturbances, such as obesity, dyslipidemia and diabetes, can promote the aging process and the onset of multimorbidity. He is particularly interested in the role that sex hormones play in regulating these processes due to gender-specific disparities in metabolic disease, inflammatory disorders, and healthspan across the life-cycle. The long-term goal of Dr. Stout laboratory is to develop therapeutic strategies that target metabolic signaling pathways in a manner similar to calorie restriction, thereby diminishing age-related diseases and compressing the period of morbidity in mid-to-late life.