Department of Nutritional Sciences

Michael Stout, PhD

Assistant Professor


Contact Information:

(405) 271-8001 Ext. 41177

Michael-Stout@ouhsc.edu


Education:

Postdoctoral Fellow, Basic Biology of Aging, Kogod Center on Aging, Mayo Clinic, 2011-2016
PhD, Nutrition & Metabolism, Ohio State University, 2005-2011
MA, Exercise Physiology, University of Central Florida, 2003-2005
BS, Engineering Technology, Bowling Green State University, 1996-2001


Research Interests:

The central focus of Dr. Stout’s research program is to understand how metabolic disturbances such as obesity, dyslipidemia, and diabetes can promote the aging process and the onset of multimorbidity. He is particularly interested in the role that sex hormones play in regulating these processes due to gender-specific disparities in metabolic disease, inflammatory disorders, and healthspan across the life-cycle. The long-term goal of Dr. Stout laboratory is to develop therapeutic strategies that target metabolic signaling pathways in a manner similar to calorie restriction, thereby diminishing age-related diseases and compressing the period of morbidity in mid-to-late life.


Dr. Stout's Video


Funding:

Current funding, see CV for complete list

  • Mechanisms of metabolic, inflammatory, and healthspan enhancement by 17α-estradiol
    Agency: NIH/NIA
    Type: K99/R00
    Amount: $1,024,528 (direct)
    Period: April 2016-March 2021
    Role: PI


Selected Publications:

Selected publications, see CV for complete list:

  • Chucair-Elliott AJ, Ocanas SR, Stanford DR, Hadad N, Wronowski B, Otalora L, Stout MB, Freeman WM. Tamoxifen induction of Cre recombinase does not cause long lasting or sexually divergent responses in the CNS epigenome or transcriptome. Geroscience. In Press

  • Miller BF, Pharaoh G, Hamilton KL, Peelor FF III, Kirkland JL, Freeman WM, Mann SN, Kinter M, Price JC, Stout MB. Short-term calorie restriction and 17α-estradiol administration elicit divergent effects on proteostatic processes and protein content in metabolically active tissues. J. Gerontol. A. Biol. Sci. Med. Sci. In Press

  • Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga E, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Targeting senescent cells alleviates obesity-induced metabolic dysfunction. Aging Cell. 18(3):e12950, 2019

  • Steyn FJ, Ngo ST, Chen VP, , Bailey-Downs LC, Xie TY, Ghdami M, Brimijoin S, Freeman WM, Rubinstein M, Low MJ, Stout MB. 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell. 17(1): e12703, 2018.

  • Stout MB, Justice JN, Nicklas BJ, Kirkland JL. Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty. Physiology. 32(1):9-19, 2017.

  • Stout MB, Steyn FJ, Jurczak MJ, Camporez JPG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, Santos RDS, Frank AP, White TA, Monroe DG, Singh RJ, Verzosa GC, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL. Late-life administration of 17α-estradiol alleviates metabolic and inflammatory dysfunction without inducing feminization. J. Gerontol. A. Biol. Sci. Med. Sci. 72(1):3-15, 2017.

  • Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating healthspan in pre-clinical models of aging and disease: Guidelines, challenges and opportunities for geroscience. J. Gerontol. A. Biol. Sci. Med. Sci. 71(11):1395-1406, 2016.

  • Kirkland JL, Stout MB, Sierra F. Resilience in aging mice. J. Gerontol. A. Biol. Sci. Med. Sci. 71(11):1407-1414, 2016.

  • Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise prevents diet-induced cellular senescence in adipose tissue. Diabetes. 65(6):1606-1615, 2016.

  • Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 15(3):428-435, 2016.

  • Xu M, Palmer AK, Ding H, Weivoda MW, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife. 19(4):e12997, 2015.

  • Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. JAK inhibition alleviates the cellular senescent-associated secretory phenotype and frailty in old age. Proc. Natl. Acad. Sci. USA. 112(46):E6301-E6310, 2015.

  • Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM. Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice. Oncotarget. 6(29):26702-26715, 2015.

  • Zhu Y, Tchkonia T, Pirtskhalava T, Gower A, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Borden G, Lenburg M, O’Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The achilles’ heel of senescent cells: From transcriptome to senolytic drugs. Aging Cell. 14(4):644-658, 2015.

  • Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging. 6(7):575-586, 2014.


Link to CV >