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Alexander Mdzinarishvili, PhD

College of Allied Health
University of Oklahoma Health Sciences Center
1200 North Stonewall Ave.,
Oklahoma City, OK 73117-1215
PO Box 26901,
Oklahoma City, OK 73126-0901

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Alexander Mdzinarishvili

Assistant Professor

E-mail: Alexander Mdzinarishvili

(405) 271-2131 Ext. 47128

Ph. D. in Physiology and Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, 1990

M.S. in Physiology/Neuroscience, Institute of Physiology, Georgian Academy of Science, Tbilisi, Republic of Georgia, 1985

B.S. in Biology, Georgia State University, Tbilisi, Republic of Georgia, 1980     

Professional Program:

AHS 8275 Neuroscience (5 credits, course coordinator)
PHTH 8172 Measurement in Clinical Practice (2 credits, course coordinator)

Sadana P., Coughlin L., Burke J., Woods R., Mdzinarishvili A. (2015) Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: possible association with AQP4 modulation. J. of the Neurological Sciences DOI: 10.1016/j.jns.2015.04.042

Geldenhuys W. J., Mdzinarishvili A., Carroll R., Lin L., (Dec., 2014) The mito-NEET ligand NL-1 protection in transient ischemic stroke through an ERK1/2 kinase pathway. Journal of  Neurochemistry (submitted)

Mdzinarishvili A., Sutariya V., Talasila P., Aring D., Geldenhuys W., Sadana P., (2013)  Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke. J. Drug   Delivery and Translational Research (2013) 3:pp.309–317. (DDTR - Best paper 2013 award recipient)

Mdzinarishvili A., Sumbria R., Lang D., Klein J., (2012) Ginkgo Extract EGb761 Confers Neuroprotection by Reduction of Glutamate Release in Ischemic Brain. J. Pharmacy and  Pharm. Sci., 15(1), pp. 94 - 102.

Lang D., Kiewert C., Mdzinarishvili A., Schwarzkopf T., Sumbria R., Hartmann J.,  Klein J.,  (2011) Neuroprotective Effects of Bilobalide are Accompanied by a Reduction of Ischemia- Induced Glutamate Release in vivo. J. Brain Research 1425, pp. 155-63.

Kiewert C., Mdzinarishvili A., Hartmann J., Bickel U.,  Klein J., (2010) Metabolic and  Transmitter Changes in Core and Penumbra after Middle Cerebral Artery Occlusion in Mice. J. Brain Research  1312, pp. 101-107.

Paulson, J.R., Yang, T., Selvaraj P.K., Mdzinarishvili A., Van der Schyf, C.J., Klein, J., Bickel, U., Abbruscato T.J., (2010) Nicotine Exacerbates Brain Edema During in vitro and in vivo Focal Ischemic Conditions. J. Pharmacol. Exp. Ther.,332(2), pp. 371-379.

Hao J., Mdzinarishvili A., Abbruscato T.J., Klein J., Geldenhuys W.J., Van der Schyf C.J.,  Bickel U., (2008) Neuroprotection in Mice by NGP1-01 after Transient Focal Brain Ischemia. J. Brain Research, 1196, pp. 113-120.

Mdzinarishvili A., Kiewert C., Kumar V., Hillert M., Klein J., (2007) Bilobalide Prevents Ischemia-induced Edema Formation in vitro and in vivo. Neuroscience, 144(1), pp. 214-222.  

Crews F., Mdzinarishvili A., Kim D., He J. and Nixon K., (2006) Neurogenesis in Adolescent Brain is Potently Inhibited by Ethanol. Neuroscience, 137(2), pp. 437-445.

Kumar V., Mdzinarishvili A., Kiewert C.,  Abbruscato T.J., Bickel U.,  Van der Schyf, C.J., Klein J., (2006) NMDA-receptor Antagonistic Properties of Hyperforin, a Constituent of St. John’s Worth. J. Pharmacy and Pharm. Sci. 102(1), pp. 47-54.

Mdzinarishvili A., Geldenhuys W.J., Abbruscato T.J., Bickel U., Klein J., Van der Schyf, C.J., (2005) NGP1-01, a Lipophilic Polycyclic Cage Amine is Neuroprotective in Focal Ischemia.  J. Neuroscience Letters, v. 383(1-2), pp. 49-53.    

Seredenin S.B., Voronina T.A., Burlakova E.B., Molodavkin G.M., L.I. Tchernyavskaya, Khorseva N.I., Mdzinarishvili A., (1994) Peculiarities of Phenazepam Anticonflict Action in Rats Picked Up by Means of Forced Swimming Techniques. J. Vyssh., Nervn., Dehyat., 44(4-5), pp. 831-836.

Molodavkin G.M., Voronina T.A., Mdzinarishvili A., (1994) Specific Features of Effects of  Different Classes on Forced Swimming in Rats. J. Exp.and Clin.Pharmocol., 57(1), pp.3-5.

Voronina T.A., Meerson F.Z., Mdzinarishvili A., Abdikaliev N.A., Pshennikova M.G. (1990) Comparison of Anticonvulsant and Antiarrhythmic Effects of the Benzodiazepine Receptor Agonist Phenazepam. Bull. Exp. Biol. and Med., 109(2); pp. 158-161.

Mdzinarishvili A., Molodavkin G.M., Voronina T.A. (1989) Influence of Valproic Acid on Sleep Structure and Ethanol Consumption in Rats with Different Types of Individual Reactivity, Before and After Stress. Bull. Exp. Biol. and Med., 108(9), pp. 294-296.

Mdzinarishvili A., Molodavkin G.M. (1988) Influence of Valproic Acid of the Ethanol Intake in the Rats with Different Individual Reactivity, After Paradoxical Sleep Deprivation. Proc. of the Acad. Sci. of the Georgian SSR, Biol. Series, 14( 5),  pp. 357-359.

Mdzinarishvili A,, Molodavkin G.M. (1988) Effect of Paradoxical Sleep Deprivation on Ethanol Consumption in Rats with Different Degrees of Predisposition to Depression - Like States. Bull. of the Acad. Sci. of the Georgian SSR, "Moambe", 130(1), pp. 173-176. 

Translational research of brain stroke and edema formation 

Translational research of neural stem cells under brain stroke conditions