Stefano Tarantini, PhD

Office: BRC 1315B
Lab: BRC 1313

Mailing address
975 NE 10th street, BRC 1313
Oklahoma City, OK 73104

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Education:

• Postdoctoral Fellowship, Reynolds Oklahoma Center on Aging 2016-2019, Oklahoma City
• Ph.D. 2016, University of Oklahoma Health Sciences Center, Physiology (Cum Laude)
• B.S. 2012, University of Central Oklahoma, Biomedical Engineering (Magna Cum Laude)

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Clinical/Research Interests:

• Vascular contributions to cognitive impairment and dementia (VCID)
• Mechanisms of vascular aging
• Age-related endothelial dysfunction
• Neurovascular coupling
• Intra-cerebral microhemorrhages (microbleeds)
• Cerebrovascular reactivity
• Senolytics therapies
• Nutritional anti-aging interventions

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Select Publications:

• Mechanisms of Vascular Aging. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Circ Res. 2018 Sep 14;123(7):849-867.  doi: 10.1161/CIRCRESAHA.118.311378. Review. PMID: 30355080 
• Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Nat Rev Cardiol. 2018 Sep;15(9):555-565. doi: 10.1038/s41569-018-0030-z. Review. PMID:  29795441 
• Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Tarantini S, Tran CHT, Gordon GR, Ungvari Z, Csiszar A. Exp Gerontol. 2017 Aug;94:52-58. doi: 10.1016/j.exger.2016.11.004. Epub 2016 Nov 12. Review. PMID:  27845201 
• Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging. Toth P, Tarantini S, Csiszar A, Ungvari Z. Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20. doi: 10.1152/ajpheart.00581.2016. Epub 2016 Oct 28. Review. PMID:  27793855 
• Cerebral microhemorrhages: mechanisms, consequences, and prevention. Ungvari Z, Tarantini S, Kirkpatrick AC, Csiszar A, Prodan CI. Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1128-H1143. doi: 10.1152/ajpheart.00780.2016. Epub 2017 Mar 17. Review. PMID:  28314762 
• Nicotinamide mononucleotide (NMN) supplementation rescues  erebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID:  31015147 
• Role of endothelial NAD₊ deficiency in age-related vascular dysfunction. Csiszar A, Tarantini S, Yabluchanskiy A, Balasubramanian P, Kiss T, Farkas E, Baur JA, Ungvari Z.Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1253-H1266. doi: 10.1152/ajpheart.00039.2019. Epub 2019 Mar 15. PMID:  30875255
• Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Fulop GA, Kiss T, Tarantini S, Balasubramanian P, Yabluchanskiy A, Farkas E, Bari F, Ungvari Z, Csiszar A. Geroscience. 2018 Dec;40(5-6):513-521. doi: 10.1007/s11357-018-0047-6. Epub 2018 Nov 23. PMID:  30470983 
• Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment. Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Geroscience. 2019 Oct;41(5):619-630. doi: 10.1007/s11357-019-00074-2. Epub 2019 May 29. PMID:  31144244 
• Assessment of endothelial function in leptomeningeal arterioles derived from patients with Alzheimer's disease and vascular cognitive impairment. Toth P, Tarantini S, Rutkai I, Ungvari Z. Am J Physiol Heart Circ Physiol. 2018 Oct  1;315(4):H790-H793. doi: 10.1152/ajpheart.00367.2018. Epub 2018 Jun 22. No abstract available. PMID:  29932773 
• Astrocyte senescence contributes to cognitive decline. Csipo T, Lipecz A, Ashpole NM, Balasubramanian P, Tarantini S. Geroscience. 2019 Nov 26. doi:  0.1007/s11357-019-00140-9. [Epub ahead of print] No abstract available. PMID:  31773453
• Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177. PMID:  29905772 
• Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H. Redox Biol. 2018 Jul;17:47-58. doi: 10.1016/j.redox.2018.04.004. Epub 2018 Apr 6. No abstract available. PMID:  29673700 
• Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice. Tarantini S, Yabluchanskiy A, Fülöp GA, Hertelendy P, Noa Valcarcel-Ares M, Kiss T, Bagwell JM, O'Connor D, Farkas E, Sorond F, Csiszar A, Ungvari Z. Geroscience. 2018 Apr;40(2):219. doi: 10.1007/s11357-018-0012-4. PMID:  29468558
  
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