Norman Hord, PhD, MPH, RD

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Education:

• Master of Public Health, Epidemiology, Johns Hopkins University, Baltimore, MD, 1995 
• Doctor of Philosophy, Nutrition, Purdue University, West Lafayette, IN, 1994
• Master of Science, Nutrition, Clemson University, Clemson, SC, 1988
• Bachelor of Science, Foods and Nutrition, Michigan State University, East Lansing, MI, 1983

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Clinical/Research Interests:

• Dr. Hord supervises a research program that focuses dietary nitrate and nitrite in the prevention and treatment of cardiovascular and skeletal disorders that are associated with endothelial nitric oxide (NO) deficiency. Dietary nitrate and nitrite contribute to endogenous NO production from nitrate-nitrite-NO pathway; this pathway presents new opportunities to prevent and treat hypertension and other conditions related to atherosclerotic cardiovascular disease. In this context, foods rich in nitrate and nitrite may been demonstrated to be effective for blood pressure lowering, stabilization of atherosclerotic plaques and improve athletic performance in adults.

 

Topical list:

• Diet-related risk factors for cardiovascular disease, diabetes and cancer
• Metabolic determinants of the cardiovascular effects of dietary nitrate

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Funding:

• “Pilot Study of a Metabolic Therapy for the Management of Primary Brain Tumors”, American Institute for Cancer Research, Kenneth Schwartz, Norman Hord, L. Karl Olson, Mary Noel, Howard Chang, Michele Nikolai, 2013-2015, $170,000.00.
   
• “Effects of exposure to nitrate and nitrite on zebrafish fetal cardiovascular development and zebrafish performance”, Environmental Health Sciences Core Center Pilot Grant Program, Oregon State University, 2013-2014, $25,000.00.
   
• “Effect of whole grain components on inflammation and glucose intolerance in a mouse model”, Emily Ho, Andriy Morgan, Natalia Shulashenko, Carmen Wong, Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health, Oregon State University, 2013-2014, $25,000.00.

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Select Publications:

• Keller RM, Beaver LM, Reardon PN, Prater MC, Truong L, Robinson MM, Tanguay RL, Stevens JF, Hord NG. Nitrate-induced improvements in exercise performance are coincident with exuberant changes in metabolic genes and the metabolome in zebrafish (Danio rerio) skeletal muscle. J Appl Physiol (1985). 2021 Jul 1;131(1):142-157. doi: 10.1152/japplphysiol.00185.2021. Epub 2021 May 27. PMID: 34043471; PMCID: PMC8325611.
• García-Jaramillo M, Beaver LM, Truong L, Axton ER, Keller RM, Prater MC, Magnusson KR, Tanguay RL, Stevens JF, Hord NG. Nitrate and nitrite exposure leads to mild anxiogenic-like behavior and alters brain metabolomic profile in zebrafish. PLoS One. 2020. Dec 31;15(12):e0240070. doi: 10.1371/journal.pone.0240070. PMID: 33382700; PMCID: PMC7774831.
• Moua ED, Hu C, Day N, Hord NG, Takata Y. (2020) Coffee Consumption and C-Reactive Protein Levels: A Systematic Review and Meta-Analysis. Nutrients 12 (5), 1349. doi:10.3390/nu12051349.
• Axton, ER, Beaver, LM Lindsey St. Mary, L, Truong, L, Logan, CR, Spagnoli, S, Mary C. Prater, MC, Keller, RM, Garcia-Jaramillo, M, Ehrlicher, SE, Stierwalt, HD, Newsom, SA, Robinson, MM, Tanguay, RL, Stevens, JF and Hord, NG  (2019) Treatment with nitrate but not nitrite lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish, J Nutr, 149 (12): 2120–2132.
• Keller RM, Beaver, L, Prater, MC, Hord, NG. (2017) Dietary nitrate and nitrite concentrations in food patterns and dietary supplements. Nutrition Today, DOI: 10.1097/NT.0000000000000253.
• Conley MN, Roberts C, Sharpton TJ, Iwaniec UT, Hord NG. (2017) Increasing dietary nitrate has no effect on cancellous bone loss or fecal microbiome in ovariectomized rats. Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/ mnfr.201600372.
• Hord, NG and Conley M. (2017) Regulation of dietary nitrate and nitrite: balancing essential physiological roles with potential health risks, In: Nitrates and Nitrites in Human Health and Disease, Editors: Joseph Loscalzo, M.D., Ph.D. (Harvard University) and Nathan S. Bryan, PhD (Texas), New York, NY, Springer Science and Business Media, Second Edition, ISBN 978-3-319-46189-2.
• Ahluwalia, A, Gladwin, M, Coleman, GD, Hord, NG, Howard, G, Kim-Shapiro, D, Lajous, M, Larsen, F, Lefer, DJ, McClure, LA, Nolan, BT, Pluta, R, Schechter, A, Wang, C-Y, Ward, MH, and Harman, JL (2016) Dietary nitrate and the epidemiology of cardiovascular disease: Report from a National Heart, Lung, and Blood Institute Workshop, Journal of the American Heart Association, Jul; 5(7): e003402. Published online 2016 Jul 6. doi: 10.1161/JAHA.116.003402.
• Conley MN, Wong CP, Duyck KM, Hord N, Ho E, Sharpton TJ. (2016) Aging and serum MCP-1 are associated with gut microbiome composition in a murine model.  PeerJ. Mar 31;4:e1854. doi: 10.7717/peerj.1854.
• Schwartz, K, Chang HT, Nikolai, M, Pernicone, J, Rhee, S, Olson, K, Kurniali PC, Hord, NG; Noel, M. (2015) Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer & Metabolism 3:3, DOI: 10.1186/s40170-015-0129-1.