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Directory

Elizabeth Hile, PT, PhD, NCS, CLT

Cancer Rehabilitation Research Laboratory (CRRL) at the OU Health Stephenson Cancer Center

Elizabeth Hile, PT, PhD, NCS, CLT

  • Associate Professor
  • Program Director, PhD Program
  • Director, Cancer Rehabilitation Services and Research Lab @ OU Stephenson Cancer Center
(405) 271-2273

Elizabeth-Hile@ou.edu

Education:

  • Post-doctoral Scholar, Aging Research, Pittsburgh Pepper Older Americans Independence Center (NIH/NIA P30AG024827, PI/Mentor: Stephanie Studenski MD, MPH) 2010-2013
  • PhD, Rehabilitation Science, University of Pittsburgh, Pittsburgh, PA 2010
  • MS, Physical Therapy with Neuromuscular Focus, University of Pittsburgh, Pittsburgh, PA, 1999
  • MPT, Physical Therapy, University of Pittsburgh, Pittsburgh, PA, 1996
  • BS, Biochemistry, SUNY at Geneseo, Geneseo, NY 1994

Teaching:

Professional Program:

  • PHTH 8282: Clinical Reasoning in PT I (Primary Instructor and Course Coordinator)
  • PHTH 9152: Clinical Reasoning in PT II (Group Facilitator)
  • PHTH 9173: Complex Medical Problems (Course Co-Coordinator)
  • AHS 6970 Allied Health Doctoral Seminar Fall & Spring Term Course co-Coordinator, Interprofessional Rehabilitation & Nutritional Sciences
  • AHS 6990 Special Studies, Primary Instructor and Course Coordinator for 3 Elective Course Options
    • Clinical Reasoning for the PhD
    • Cancer Rehabilitation
    • Generating Patient-Centered Research Questions
  • AHS 6960 Directed Reading: Writing Scientific Results for Publication (Primary Instructor and Course Coordinator)
  • AHS 6950 Research Practicum in Allied Health Sciences, Primary Instructor and Course Coordinator for 2 Elective Course Options
    • Secondary Data Analysis in Cancer Rehabilitation Research
    • Measurement Application in Technology-based Quantification of Foot Function and Gait
  • NURS 6323 Special Focus in Applied Statistics: Advanced Topics in Data Analysis (Lecturer on Data Pre-Processing, Interprofessional Rehabilitation & Nursing Sciences)

Societies and Organizations:


Member, Alpha Eta Honor Society

Clinical/Research Interests:

  • Balance and Gait Dysfunction in Cancer Survivors (special interest in Chemotherapy-Induced Neurotoxicity)
  • Prospective Surveillance and Rehabilitation of Side-Effects of Cancer Treatments
  • Measurement of and Interventions for Balance and Mobility Decline in Older Adults
  • Exercise and Nutrition Pre-Surgical Rehabilitation (Prehab) for Improved Survival Outcomes in Cancer
  • Cancer Rehabilitation

Funding:

  • Presbyterian Health Foundation (PHF) Clinical Translational Grant Award. Responsiveness of QuHalEx Output to Lower Body Rehabilitation in Cancer Survivorship.  Role: mPI, pending final NOA for potential start Oct 1, 2024-2026. $200,000.
  • Stephenson Cancer Center (SCC) Investigator-Initiated Trials (IIT). Leveraging QuHalEx and Artificial Intelligence Algorithms for Earlier Detection and Management of Distal Neuromyopathies in Blood Cancer Survivors at SCC. Role: PI,  2024-25. $100,000.
  • Stephenson Cancer Center (SCC) Investigator-Initiated Trials (IIT). Circulating Tumor DNA Response Adapted Treatment De-Escalation in Metastatic Urothelial Carcinoma (CT-READ).  Role: co-I for quantification of peripheral neurotoxicity,  2024-25. $100,000.
  • SCC NCI P30 Cancer Center Support Grant Trainee Award. Examining Associations between Functional Cognition and Dual-Task Gait Performance in Women with Cancer. Role: Primary Mentor to PhD Trainee, 2023-24. $5,000
  • National Science Foundation (NSF) Southwest I-Corps™ Hub at Oklahoma State University. Defining a Market for Commercialization of Quantification of Hallux Extension (QuHalEx) Technology. Role: Project Director/ Team Lead; Summer 2023. $5,000.
  • SCC NCI P30 Cancer Center Support Grant Cancer Therapeutics/Cancer Prevention and Control (CPC) Collaborative Pilot Grant. Examining Associations between Functional Cognition and Dual-Task Gait Performance in Women with Cancer. Role: CPC mPI, 2020-21 with no-cost extension through 2023 for COVID-19. $19,980.

Patents/ Intellectual Property: 

  • Hile E, Refai H, Sedoun MY, Cha A, Rippetoe J. U.S. Patent Application No. 63/627,850. Improved Measuring Apparatus and Method for Evaluating Foot Health (a.k.a. Quantification of Hallux Extension, QuHalEx ver2) Issue Date: 02/01/2024.
  • Hile E, Wang H, Ghazi M. U.S. Patent No. 11402284 Apparatus and Method for Measuring Toe Flexion and Extension Strength. (a.k.a. QuHalEx) Issue Date: 08/02/2022.
  • Hile E and Neuhold R. High Frequency, High Volume Exercise for Cancer Prehabilitation (OUHSC Intellectual Property Disclosure D2019-0444) Filed: 09/25/2019.

Presentations:

Select Publications:

  • Seo K, Refai HH, Hile ES* (co-senior, corresponding author).  Application of Dynamic Mode Decomposition to Characterize Temporal Evolution of Plantar Pressures from Walkway Sensor Data in Women with Cancer. Feature Paper in MDPI Sensors. 2024; 24(2):486.  https://doi.org/10.3390/s24020486 
  • Hile E, Ghazi M, Chandrashekhar R, Rippetoe J, Fox A, Wang, H.  Development and Earliest Validation of a Portable Device for Quantification of Hallux Extension Strength (QuHalEx) Sensors. 2023:23;10:4654.
  • Hile E and Neuhold R. Using Frequency to Bolus-dose Resistance Training for Brief Pre-operative Windows in Geriatric Abdominopelvic Cancers Prehabilitation. 2022 Jun;13(5):747-753. doi: 10.1016/j.jgo.2022.02.012. Epub 2022 Mar 8. PMID: 35277371; PMCID: PMC9233010.
  • Harrington SE, Stout NL, Hile E, Fisher MI, Eden ME, Marchese V, Pfalzer L. Cancer Rehabilitation Publications (2008-2018) With a Focus on Physical Function: A Scoping Review. Phys Ther. 2020; 100(3): 363-415. 
  • Huang MH, Hile ES, Croarkin E, Wampler-Kuhn M, Blackwood J, Colon J, Pfalzer C. Academy of Oncologic Physical Therapy EDGE Task Force: A Systematic Review of Measures of Balance in Adult Cancer Survivors. Rehab Oncol. 2019;37(3):92-103. 
  • Schneider M, Ammendolia C, Murphy D, Glick R, Hile E, Tudorascu D, Morton SC, Smith C, Patterson CG, Piva SR. Comparative Clinical Effectiveness of Non-Surgical Treatment Methods for Patients with Lumbar Spinal Stenosis: A Randomized Clinical Trial. JAMA Netw Open. 2019; 2(1):e186828. PMID: 30646197. 

Published Abstracts at National or International Conferences (*Mentee as first author)

  • Hile ES, Xu C, Feierabend D, Cha A, Neuhold R, McIntire A, Phi P, Nipp R, Asch A, Selby G. Retrospective Analysis of Peripheral Neuropathy in Blood Cancer Survivors Evaluated for Cellular Therapy. American Society of Clinical Oncology (ASCO) 2024 Annual Conference, Chicago, IL. Abstract ID 12087.  J Clinical Oncol. 2024, 42(16S). https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.12087 
  • *Khormi A, Cha A, Xu C, Hile E (senior). Longitudinal Associations Between Appendicular Lean Mass and Strength with Cumulative Taxane-Platinum Chemotherapy for Women’s Cancers. American Physical Therapy Association 2024 Combined Sections Meeting, Boston, MA. Rehab Oncol. 2024, 42(1).
  • Hile ES, Battung E, Cha A, Fox A, Xu C. Exploring Bioimpedance Phase Angle Trajectories after High-Frequency, High-Volume Exercise (HI-FIVE) Prehabilitation for Pancreaticoduodenectomy. Platform at American Physical Therapy Association 2023 Combined Sections Meeting (CSM), San Diego, CA. Abstract ID 38686. Rehab Oncol. 2023, 41(2): 103. 
  • *Feierabend, Desirae and Hile ES. High Frequency Training Accelerates Gait Progress for a Young Adult 1.5 Years after Cerebellar Medulloblastoma. American Physical Therapy Association 2023 CSM, San Diego, CA. Rehab Oncol. 2022, 41(2): 115. 
  • Hile E, Fox A, Bell J, Xu C, Richardson D, Moore K. Report of worse activity interference from concentration and memory problems partially explains digit symbol substitution declines during neurotoxic chemotherapy in women's cancers: exploratory analysis from an observational pilot. Abstract SIOG2022-0192 at International Society for Geriatric Oncology Geneva, Switzerland. J Geriatr Oncol. 2022 Supplement, 13(8):S34. 
  • *Neuhold R and Hile ES (senior). Hi-FiVE™: Prioritizing Exercise, Frequency over Intensity to Bolus-dose Pancreatic Cancer Prehabilitation for Brief Pre-operative Opportunities. Platform at American Physical Therapy Association 2022 CSM, San Antonio, TX. Rehab Oncol. 2022, 40(1): E12.
  • *Rippetoe J, Wang H, Xu C, Hile E (senior).  Reliability of 1st Ray Contribution to Plantar Force During Gait Push-Off in Women with Cancer.  Biomedical Engineering Society (BMES) 2021 Annual Meeting, Orlando, FL.
  • Huiwen X, Mohile S, Culakova E, Bowblis J, Intrator O, Jensen-Battaglia M, Lin P, Loh KP, Yang S, Hile E, Lund J, Mustian K. Patterns and predictors of rehabilitation therapy among older patients with advanced cancer admitted to nursing homes: a SEER-Medicare analysis. American Society of Clinical Oncology (ASCO) 2021 Annual Conference, Chicago, IL. .  J Clinical Oncol. 2021. Abstract ID 6585
  • *Neuhold RL and Hile ES (senior). Case Report of Intramuscular Dry Needling-Electrical Stimulation to Facilitate Hand Function after Brain Tumor Resection. Awarded Best Oncology Abstract at American Physical Therapy Association 2020 CSM, Denver, CO. Rehab Oncology. 2020, 38(1). Abstract ID 25755.