Education:
- Ph.D. in Nutritional Sciences, University of Oklahoma Health Campus, Oklahoma City, OK, 2025
- M.Sc. in Nutrition and Public Health, University of Sao Paulo, Sao Paulo, Brazil, 2018
- B.S. in Chemistry, University of Sao Paulo, Sao Paulo, Brazil, 2015
Teaching:
Graduate & Professional Teaching:
- NS 5833: Non-Energy Nutrients (3 credit hours)
Clinical/Research Interests:
Dr. Langley’s research agenda focuses on developing and testing dietary interventions to improve cerebrovascular health in middle-aged and older adults at risk of cognitive decline. Her overarching research goal is to provide high-quality evidence to support the translation of dietary interventions into clinical practice. Her research employs advanced neuroimaging methods (fNIRS, EEG), validated cognitive testing (MoCA, NIH Toolbox), ecological wearable health data collection (actigraphy, at-home EEG), and gold-standard clinical trial methodology with a focus on patient-reported outcomes. Ongoing projects include: 1) investigating the effect of polyphenol-derived microbial metabolite urolithin A on cerebrovascular function in middle-aged and older adults, 2) investigating the effect of time-restricted eating on cerebrovascular and cognitive outcomes, 3) characterizing the burden of food and nutrition insecurity among stroke survivors living in Oklahoma and subsequent developing of tailored Food as Medicine programs.
Funding:
- Oklahoma Shared Clinical and Translational Resources Pilot Grant, “Effect of 6 months of time-restricted eating on epigenetic aging in older adults.” Role: Co-Investigator. 01/2026–12/2026; $71,546
- Wisdom Family Foundation Interprofessional Education Research Seed Grant, “Development and delivery of a tailored nutrition workshop on mealtime challenges for caregivers of people living with dementia.” Role: MPI. 05/2024–04/2025; $3,968.00
Select Publications:
- Pinaffi-Langley ACC, Zuraikat FM, St-Onge MP, Yabluchanskiy A. Potential impact of urolithin A on pathways relevant to sleep health: a mini review. Front Nutr. 2026;13:1779855. doi: 10.3389/fnut.2026.1779855.
- Pinaffi-Langley ACC, Pinto CB, Szarvas Z, et al. Urolithin A supplementation to improve endothelial and cerebrovascular function in middle-aged adults with obesity: Study protocol for a double-blind placebo-controlled randomized study. Clin Nutr Open Sci. 2025;61:P217-230. doi: 10.1016/j.nutos.2025.04.004.
- Pinaffi-Langley ACC, Tarantini S, Hord NG, Yabluchanskiy A. Polyphenol-derived microbiota metabolites and cardiovascular health: A concise review of human studies. Antioxidants. 2024;13(12):1552. doi: 10.3390/antiox13121552.
- Pinaffi-Langley ACC, Szarvas Z, Peterfi A, et al. Time-restricted eating for prevention of age-related vascular cognitive decline in older adults: A protocol for a single-arm open-label interventional trial. PLoS ONE. 2024;19(12):e0314871. doi: 10.1371/journal.pone.0314871.
- Pinaffi-Langley ACC,# Bonin Pinto C,# Mukli P, et al. Energy metabolism dysregulation, cerebrovascular aging, and time-restricted eating: Current state of evidence and proof-of-concept findings. PNAS Nexus. 2024;3(11):pgae505. doi: 10.1093/pnasnexus/pgae505.
- Pinaffi-Langley ACC,# Nguyen HVM,# Whitehead D, et al. Nitrate and nitrite quantification in U.S. vegetable-based baby foods and infant formula via ozone chemiluminescence. J Food Compos Anal. 2024;137(part A):106902. doi: 10.1016/j.jfca.2024.106902.
- Pinaffi-Langley ACC, Dajani RM, Prater MC, et al. Dietary Nitrate from Plant Foods: A Conditionally Essential Nutrient for Cardiovascular Health. Adv Nutr. 2023:100158. doi: 10.1016/j.advnut.2023.100158.
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