Muscle Proteostasis
How does skeletal muscle maintain protein and organelle quality throughout life?
Introduce:
- autophagy
- lysosomes
- protein turnover
- protein aggregation
- ER stress
- mitochondrial quality
- proteomics
Nutrient Sensing & Cellular Quality Control
How do pathways such as mTOR and TFEB regulate the systems responsible for muscle maintenance?
This is where mechanistic work fits nicely.
Muscle Aging & Recovery
Why does aged muscle respond differently to stress, disuse, and reloading—and can cellular quality-control pathways improve recovery?
That gives a natural home for hindlimb unloading/reloading work.